In a report examining why Pfizer’s 25-valent pneumococcal vaccine infant data look strong, the analysis argues that the Phase 2 results, presented over the weekend at IDWeek 2026, represent a meaningful step in defending the larger infant market. Post Dose 4, all 20 shared PCV20 serotypes met the historical 2-fold non-inferiority criterion, and Pfizer’s modelling suggests that more than 22 of 25 serotypes would satisfy the stricter 1.5-fold threshold in a large Phase 3 study. The candidate also generated an enhanced immune response against serotype 3.
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